Nodular hidradenoma or clear cell hidradenoma is a rare skin adenexal tumor which arises from eccrine sweat glands. Nodular hidradenoma is a benign rare skin tumour arising from the eccrine type of sweat glands. A skin adnexal tumor located in the breast is unusual and is one of the differential. Webpathology is a free educational resource with 10308 high quality pathology images of benign and malignant. Poroid hidradenoma is a rare cutaneous neoplasm, most frequently situated on head and neck. We report a case in a 62 yr old male who had a slowly growing left breast lesion of 10 yrs duration. Sonographic characteristics of apocrine nodular hidradenoma of. We report a case of eccrine hidradenoma in a 31yearold man who presented with an asymptomatic, solitary nodule on occipital region. Sch, also known as clear cell hidradenoma, nodular hidradenoma, or eccrine acrospiroma, is a rare benign skin adnexal tumor of sweat gland origin. The topic malignant hidradenoma of skin you are seeking is a synonym, or alternative name, or is closely related to the medical condition hidradenocarcinoma of skin. Case report axillary nodular hidradenoma in a 29monthold girl. The cells were lying in a mucoid background along with good number of cyst macrophages figure 2.
Also known by various other names such as nodular hidradenoma, eccrine acrospiroma. Outcomesresolutions the prognosis for hidradenoma of skin is excellent with appropriate treatment, since it is a benign tumor. We describe two patients with scalp mnh with brain parenchymal invasion. Nodular hidradenoma, sweat gland neoplasms, children. Circumscribed dermal nodule with varying solid and cystic change squamous epithelial cells with clear cell changes admixed with small vessels hyalinization around. Cytological features of a cystic nodular hidradenoma. Nodular hidradenomas nhs are rare benign cutaneous adnexal neoplasms first described in 1949 as clear cell papillary carcinomas.
Nodular hidradenoma is a rare benign skin adnexial lesion of the breast. This tumor presents clinically as a solitary lesion with a cystic component. It is difficult from his work to verify this priority. This disambiguation page lists articles associated with the same title. He told me not to worry that he was sure it was nothing. Eccrine hidradenoma shows rarely low malignant potential. Poroid hidradenoma is a recently recognized variant of poroid neoplasm that should be differentiated from apocrine hidradenoma 1. It is often located in the nipple areolar region and presents as a slow growing painless lesion.
Nodular hidradenoma or clear cell hidradenoma are tumors of sweat gland usually seen in 2050 years age group with female preponderance. Because a consensus has not been reached regarding its histogenesis, eccrine hidradenoma is also known as nodular hidradenoma, clear cell hidradenoma, eccrine acrospiroma, and eccrine sweat gland adenoma. Mar 17, 2020 another name for tumors that were previously believed to strictly derive from specific sweat gland types may, in fact, derive from both eccrine or apocrine glands. The lesions are solitary and represent cutaneous and subcutaneous nodular and cystic masses of slow, expansile growth. Pdf dermoscopic features of nodular hidradenoma researchgate. Scalp is a known and yet uncommon site of occurrence. Meaning of nodular eccrine hidradenoma medical term. Hidradenoma papilliferum is a wellcircumscribed dermal nodule, usually without connection to the overlying epidermis figure 1. Nodular hidradenomas are benign sweat glandderived tumors that can produce clinical and dermatoscopic misdiagnoses. The lesion referred to is termed a hidradenoma, adenoma hidradenoides or hidradenoma tubulare. Failure to identify its morphologic features may lead to a mistaken diagnosis and over treatment. Physical examination revealed a solitary, wellcircumscribed tumor, measuring 1 cm by 0. Diagnosis of mnh and differentiation from its benign counterpart, nodular hidradenoma. If an internal link led you here, you may wish to change the link to point directly to the intended article.
Immunohistochemistry in the differential diagnosis of. There is minimal cytologic atypia, an absence of necrosis, and mitoses are not prominent. Mar 16, 2020 a total of 15 cases with features of nodular hidradenoma with their age ranging from 18 years to 73 years were studied. It is a benign neoplasm with eccrine differentiation, originally described by abenoza and ackerman in 1990. Malignant nodular hidradenoma mnh is a rare tumor of sweat gland known by many names in the literature.
Hidradenomas are often subclassified based on subtle histologic differences, for example. Werth 2 is generally credited with the first description of hidradenoma of the vulva. A single hidradenoma nodule may develop anywhere on the body, but is most likely to appear on the face, head, neck, legs, and arms. Looking for online definition of nodular eccrine hidradenoma in the medical dictionary. Immunohistochemistry in the differential diagnosis of nodula. Dec 03, 2019 pigmented nodular hidradenoma masquerading as nodular malignant melanoma. Pdf on mar 1, 2007, hind m alkatan and others published nodular hidradenoma of the lower eyelid find, read and cite all the research you need on researchgate. Hidradenoma medical definition merriamwebster medical. Poroid and clear cells this solid area of a hidradenoma is composed of small, blandappearing clear cells and poroid cells.
Nodular hidradenoma, also known as clear cell hidradenoma or acrospiroma is a benign rare skin tumour arising from the eccrine type of sweat glands. A total surgical excision was performed and histologic examination concluded to an eccrine. Nodular hidradenoma is a rare benign adnexal neoplasm classified into eccrine and apocrine types that are more often observed in adults. Acrospiroma is a cutaneous condition, primarily occurring in adult women, that is a form of benign adnexal neoplasm closely related to poroma. Glands are divided into two main groups, endocrine and exocrine. Hidradenoma is a cutaneous, often benign tumour of the sweat glands. Nodular hidradenoma nh is a benign adnexal tumor that arises from either eccrine or apocrine sweat glands. The endocrine glands, or ductless glands, discharge their secretions hormones directly into the blood. Hidradenoma is an uncommon usually benign tumor of the skin that grows slowly.
Arises from sweat gland distal excretory duct, usually solitary, on the scalp, axillae. Nodular cystic hidradenoma over the gluteal region. Sep 28, 2018 how can hidradenoma of skin be prevented. Skin adnexal tumors in plain language archives of pathology. Poroid hidradenoma ph is a rare variant of benign sweat gland neoplasm without connection to the epidermis. Hidradenoma papilliferum, also called papillary hidradenoma, is benign tumour arising from apocrine glands see sweat gland lesions. Hidradenocarcinoma originado en hidradenoma nodular. Nodular hidradenoma of left toe pubmed central pmc. Malignant nodular hidradenoma journal of the american academy. Mar 30, 20 clear cell hidradenoma or nodulocystic hidradenoma or acrospiroma are histologically distinct relatively rare tumors of sweat gland duct origin, found mainly in adults with a female preponderance.
This was a small cyst on my vulvar i had it for about 1 year before my gyno decided it was not going away on its own and should be removed. Hidradenocarcinoma of skin is a malignant tumor that may occur spontaneously or may arise from a benign hidradenoma. A lesao foi excisada e a histologia revelou um hidradenoma nodular. Skin adenexal tumors situated in the breast parenchyma are still very rare and is one of the differential diagnoses of breast tumors. The lesion is a small solitary dermal or subcutaneous nodule, most commonly on the vulva. Given the relative paucity of published data with only just over 50 case reports and small case series, there is little information available on the natural history and appropriate management for this disease. Original article by journal of evolution of medical and dental sciences.
We describe a case of a 39 patient with a breast mass. This is an openaccess article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited visit for more related articles at journal of patient care view pdf download pdf. We report a case of 45 year old female who came for fna. A cytomorphological evaluation on fine needle aspiration cytology jitendra g nasit 1, gauravi dhruva 2 1 department of pathology, government medical college and sir sayajirao general hospital, baroda, gujarat, india 2 department of pathology, pandit deendayal upadhyay government medical college and hospital, rajkot, gujarat, india. Another name for tumors that were previously believed to strictly derive from specific sweat gland types may, in fact, derive from both eccrine or apocrine glands. A special form of nodular adenoma of the vulva, arch. Pdf a 67yearsold woman was examined for a pink, solitary nodule on the upper lip skin.
Also known by various other names such as nodular hidradenoma, eccrine. If the growth becomes unsightly, it may be surgically. Nodular hidradenoma definition of nodular hidradenoma by. He remains diseasefree 5 months later and is being followed closely. Nodular hidradenoma of axilla mimicking papillary breast. Nodular hidradenoma is an established entity as a skin adnexal tumor arising from eccrine sweat glands. They described it as a rare, benign adnexal tumor with morphologic characteristics of both a poroma, with poroid and cuticular cells, and a hidradenoma, with both solid and cystic components confined solely within the dermis. Malignant transformation of nodular hidradenoma in the lower leg. The histologic distinction between nodular hidradenoma and glomus tumor is an occasional difficult diagnostic problem. Mar 20, 2020 nodular hidradenomas may be a sign of an underlying condition. Mar 05, 2020 another name for tumors that were previously believed to strictly derive from specific sweat gland types may, in fact, derive from both eccrine or apocrine glands.
Poroid hidradenoma is a benign tumor that is classified as a poroid neoplasm, and is so called because of its morphology, which is intermediate between the cytological features of a poroid. Eccrine acrospiroma definition of eccrine acrospiroma by. Clear cell hidradenoma or nodulocystic hidradenoma or acrospiroma are histologically distinct relatively rare tumors of sweat gland duct origin, found mainly in adults with a female preponderance. Abstract nodular hidradenoma is a benign adnexal tumor with eccrine differentiation, occurring mainly in adults average age of 37. Hidradenoma of the vulva jama dermatology jama network. The lesion is a small solitary dermal or subcutaneous nodule, most commonly on the vulva histology of hidradenoma papilliferum. Our findings indicate that solidcystic hidradenoma of the skin represents a clinically and microscopically distinct sweat gland neoplasm which should be separated from other types of hidradenomas and appendageal tumors. Pigmented nodular hidradenoma jama dermatology jama. Currently, there are no known methods to prevent hidradenoma of skin occurrence. Malignant nodular hidradenoma of scalp pubmed central pmc. The microscopy revealed that the resected skin margins were free. It presents architectural features of hidradenoma, with solid and cystic areas and tumor cells restricted to the dermis, and cytological features of poroid neoplasm such as poroid and cuticular cells. Both tumors may show circumscribed aggregates of uniform epithelioid cells, a myxoid stroma, and variable numbers of blood vessels.
Nodular hidradenomas may be a sign of an underlying condition. I have just been diagnosed with hidradenoma papilliferum. Nodular hidradenoma nh is a benign adnexal tumor that arises. Since then, less than 20 cases of poroid hidradenoma have been reported in the literature. Nests lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia. Please note, molecular genetic changes are also called somatic.
Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. Clear cell hidradenoma definition of clear cell hidradenoma. Subscribe to americas largest dictionary and get thousands more definitions and advanced searchad free. Hidradenoma definition of hidradenoma by medical dictionary. Nodular hidradenoma, also known as eccrine acrospiroma, is a benign adnexal skin tumour. Hidradenoma article about hidradenoma by the free dictionary. The breast is a rare site for this lesion, with only two documented cases, which were determined based on mammogram and sonogram findings. It usually presents as a single, small skincolored lesion, and is considered distinct from the closely related poroma. Malignant nodular hidradenoma mnh or nodular hidradenocarcinoma is a rare malignant adnexal tumor that represented hidradenoma is an uncommon usually benign tumor of the skin that grows slowly. Nodular hidradenoma of axilla mimicking papillary breast neoplasm a case report. Clear cell hidradenoma is an uncommon benign skin appendageal tumor that typically involves the dermal layer of the head, face, and extremities. A total of 15 cases with features of nodular hidradenoma with their age ranging from 18 years to 73 years were studied. Thus the cytologic diagnosis was given as cystic hidradenoma.
To develop an immunohistochemical profile useful in this differential diagnosis, 25 selected skin tumors and four normal glomus bodies were studied with antibodies against low molecularweight cytokeratin cam 5. Hidradenoma definition of hidradenoma by the free dictionary. Mar 16, 2020 webpathology is a free educational resource with 10308 high quality pathology images of benign and. In five benign nodular sweat gland tumors, areas of melanin pigmentation were found within the tumor parenchyma. Hidradenocarcinoma genetic and rare diseases information. Nodular hidradenoma of axilla mimicking papillary breast neoplasm a case report they can be clinically confused with other lesions that can appear in this area such as malignancies and less frequently other benign neoplasms, such as lipomas. The formation of these benign sweat gland tumors is one of the symptoms of eccrine acrospiroma. Eccrine hidradenoma is a rare benign cutaneous neoplasm, believed to arise from the distal excretory duct of the eccrine sweat glands. They are very aggressive neoplasms that recur locally and frequently metastasize to the lymph nodes. The only known risk factor is the prior presence of a benign hidradenoma molecular genetic changes in the cells of the hidradenocarcinoma have been found in some cases, but more studies must be performed before medical researchers can determine if a pattern exists.